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Vitamin D: Preeclampsia

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By: Sean Moloughney

Editor, Nutraceuticals World

Nutraceutical: Vitamin D
 
Indication: Preeclampsia
 
Source: Am J Obstet Gynecol, August 9, 2010: Epub ahead of print.
 
Research: Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE). Researchers enrolled 50 subjects with EOSPE (<34 weeks’ gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with 100 gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.
 
Results: Subjects with EOSPE were noted to have decreased total 25-OH-D levels relative to healthy control subjects. This difference in total 25-OH-D remained significant after control for potential confounders. Total 25-OH-D is decreased at diagnosis of EOSPE, but researchers say further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.

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